Beauty of Black and White: Autofluorescence Aided Differentiation of Serpiginous Choroiditis from Tubercular Serpiginous-Like Choroiditis

Theme: Uveitis
What: Uveitis
Part of: Uveitis I: Innovative Imaging Techniques in Uveitis: Exploring Beyond the Traditional. / Uvéite I: Techniques d’imagerie innovantes pour l’uvéite : Explorer au-delà des techniques classiques
When: 5/31/2024, 11:15 AM - 12:45 PM
Where: Room | Salle 714 B

Abstract

Purpose

To characterize fundus autofluorescence (FAF) images for differentiating serpiginous choroiditis (SC) from tubercular serpiginous-like choroiditis (TB SLC).

Study Design

Retrospective cohort study

Methods

The index study is a retrospective comparative analysis of FAF images of 25 consecutive patients, 11 with TB SLC and 14 with SC. The diagnosis of SC was made based on the clinical appearance and FAF findings, while TB SLC was additionally considered in patients with positive laboratory investigations and/or radiological tests for tuberculosis (TB) exposure or infection and therapeutic response to anti-tubercular therapy. The characteristic features evaluated on FAF images were centrality, multifocality, and parapapillary involvement of the lesion with or without extension.

Results

Twenty-five patients (13 males, 12 females) with a mean age of 46.2 (SD 10.08) years were enrolled in the study. SC lesions were more central (ρ=0.92) and confluent (ρ=0.774). Parapapillary involvement was found to be associated with SC (ρ=0.690), and with extensions of the lesions along the arcades or the macular region, the association increased (ρ=0.786). Multifocality with peripheral lesions was negatively associated with SC (ρ=- 0.831).

Conclusions 

Centrally involving lesions with confluency on FAF is strongly associated with SC. Parapapillary involvement alone is considered characteristic for SC, but the current study has demonstrated that extension of this lesion along the arcades or the macular region is even more characteristic for SC.

Presenter(s)

Presenting Author: Eunice Linh You

Additional Author(s):

Anadi Khatri, Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA

Muna Kharel, Birat Eye Hospital, Biratnagar, Nepal

Quan Dong Nguyen, Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA

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