Evolution of retinal nerve fiber layer and ganglion cell layer thickness in Birdshot chorioretinopathy by initial presentation

Theme: Uveitis
What: Uveitis
Part of: Uveitis I: Innovative Imaging Techniques in Uveitis: Exploring Beyond the Traditional. / Uvéite I: Techniques d’imagerie innovantes pour l’uvéite : Explorer au-delà des techniques classiques
When: 5/31/2024, 11:15 AM - 12:45 PM
Where: Room | Salle 714 B

Abstract

Purpose: To characterize the evolution of retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness in Birdshot chorioretinopathy (BSCR) based on initial presentation.

Study design: Retrospective cohort study.

Methods: Patients with BSCR followed by the uveitis service of the Centre universitaire d’ophtalmologie – Hôpital Maisonneuve-Rosemont were considered for inclusion (n=172 eyes). They were categorized based on initial presentation: inflammatory presentation with hot disc, vasculitis, and cystoid macular edema (CME); CME only; and no inflammatory component. Differences between initial and final RNFL and GCL measurements were compared using Wilcoxon signed-rank test and subsequently compared between presentation groups.

Results: Median [Q1, Q3] age at presentation was 53 [46, 59] years and 57% were female. Follow-up time was 4.2 [2.1, 5.6] years for RNFL and 6.8 [3.0, 9.4] years for GCL. Initial and final RNFL thickness were 100 [90, 127] and 94 [84, 105] (p<0.001), while initial and final GCL thickness were 65 [48, 76] and 60 [48, 71] (p=0.001). When comparing differences in initial and final RNFL and GCL measurements by presentation, there were no significant differences between presentations (p=0.39 for RNFL and p=0.85 for GCL).

Conclusions: RNFL and GCL measurements decrease over time in BSCR patients, but these do not seem to be further affected by extent of inflammation at initial presentation.

Presenter(s)

Presenting Author: Daniel Chow

Additional Author(s):

Mélanie Hébert, Ophthalmology Resident - (Université Laval)

William Sebag, Université de Montréal

Keith Perry, Université de Montréal

Anna Polosa, Visual Electrophysiology Specialist (Hôpital Maisonneuve-Rosemont)

Marie-Josée Aubin, Université de Montreal

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