Clinical outcomes of novel double layered 9mm dehydrated amniotic membrane disc

Theme: Cornea, external disease & refractive surgery
What: Cornea, external disease & refractive surgery
Part of: Cornea II: Medical Cornea and Ocular Surface / Cornée II: Cornée médicale et surface oculaire
When: 5/31/2024, 02:00 PM - 03:30 PM
Where: Room | Salle 713 AB

Abstract

Purpose: To evaluate the clinical outcomes of a novel double layered  9mm dehydrated amniotic membrane disc in patients with ocular surface disorders.

Study design: Retrospective case series

Methods: A retrospective analysis of 9 eyes of 9 patients treated with double layered dehydrated amniotic membrane was performed. Included patients had limbal stem deficiency (n=6), neurotrophic cornea (n=2), and conjunctival lesion (n=1). Clinical outcomes included changes in slit lamp findings and visual acuity.  

Results: Of 9 patients, 6 were males and the rest females with a mean age of 56.2±21.9 years (range 33-98). Post-procedure, patients were evaluated from any time between 1 to 18 weeks (median 2.4 weeks). The total mean follow-up was 7.72±5.3 months (range 0.33-14.7, median 9.33). At first follow-up, all patients showed improvement in clinical signs, and the dehydrated amniotic membrane was integrated in all except one (shifted nasally). Visual acuity pre-procedure was 1.57±0.92 logMAR units (range 0.1-3, median 1.3), which improved to 1.04±0.75 logMAR units (range 0.1-2.5, median 1) at first follow-up (p-value 0.00819), and 0.86±0.49 (range 0.1-1.7, median 1) at the last follow-up (p-value 0.00551).

Conclusion: The novel double layered 9mm dehydrated amniotic membrane shows significant improvement in clinical signs and visual acuity in patients with ocular surface disorders.

Presenter(s)

Presenting Author: Manokamna Agarwal

Additional Author(s):

Mor Bareket, University of Toronto

Alonso Gutierrez Guerinoni, University of Toronto

Erica Darian-Smith, University of Toronto

Mariana Collazos, University of Toronto

David Rootman, University of Toronto

Clara Chan, University of Toronto

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