Adaptive Optics Imaging in Retinal Detachment: A Retrospective Analysis

Theme: Retina*
What: Retina
Part of: Retina III: A Passionate Potpourri for Pinching Out Pathology / Rétine III: Pot-pourri passionné pour éliminer les pathologies
When: 6/2/2024, 11:15 AM - 12:45 PM
Where: Room | Salle 713 AB

Abstract

Purpose: To investigate the associations between adaptive optics (AO) photoreceptor parameters and clinical outcomes in retinal detachment (RD) patients post-RD surgery.

Study Design: Retrospective, observational cohort study.

Methods: Patients with RD over the age of 18 years old that underwent AO imaging following RD repair were included. AO imaging was performed using the RTX1 camera (Imagine Eyes, Orsay, France) and data pertaining to the following photoreceptor parameters were collected: cone regularity, density, spacing, and dispersion. Associations between photoreceptor parameters and logMAR BCVA, metamorphopsia, and aniseikonia were examined using multivariable regression models on Stata v.17.0 (StataCorp LLC, College Station, Texas), adjusting for age, sex, and the number of days between AO imaging and each outcome. 

Results: Across 49 patients imaged with AO, 41 RD eyes and 28 control eyes were included in our analysis. BCVA was associated with cone spacing at 2° (p=0.033) and 4° eccentricities (p=0.016). Moreover, BCVA was inversely associated with cone density at 2° (p=0.045) and 4° eccentricities (p=0.009). Vertical and horizontal metamorphopsia were both inversely associated with cone density at 2° (p=0.029 and p=0.034, respectively) and 4° (p=0.012 and p=0.013, respectively) eccentricities. Vertical metamorphopsia was also associated with cone spacing at 4 degrees of eccentricity (p=0.020). The difference in cone dispersion between eyes was associated with vertical (p=0.033 and p=0.016, respectively) and horizontal aniseikonia (p=0.025 and p=0.022, respectively) at 2° and 4° eccentricities, respectively.

Conclusions: Several changes in AO photoreceptor architecture were significantly associated with clinical outcomes in RD patients post-RD surgery. Future prospective trials should explore associations between clinical characteristics and AO parameters in diverse RD patient populations.

Presenter(s)

Presenting Author: Andrew Mihalache

Additional Author(s):

Ryan Huang, University of Toronto

Marko Popovic, University of Toronto

Michael Balas, University of Toronto

Mariam Issa, University of Toronto

Isabela Melo, University of Toronto

Aurora Pecaku, University of Toronto

Sue Demian, University of Toronto

Rajeev Muni, University of Toronto

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